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Insulin shock therapy
Insulin shock therapy (IST, also called Insulin Coma Therapy) was used as a treatment for schizophrenia, psychosis and drug addiction, involving injecting the patient with massive amounts of insulin, which causes convulsions and coma. It was developed by Polish researcher Manfred Sakel in 1933 and was used well into the 1950s, being replaced by tranquilizing drugs and then later anti-psychotic drugs as well (which also have a sedative effect).
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